Jennifer Phillips Cremins awarded CZI grant as part of the Neurodegeneration Challenge Network

Posted On: September 10, 2020

As neurodegenerative diseases, like Alzheimer’s, Parkinson’s, and ALS, continue to rise as a leading cause of death worldwide, the Chan Zuckerberg Initiative launched the Neurodegeneration Challenge Network. This collaboration brings scientists together from across research fields to study the fundamental biology of neurodegenerative diseases with the goal of producing significant advancements in prevention, detection, and treatment.

Alongside Kristen Brennand, from the Icahn School of Medicine at Mount Sinai, the project will investigate the emerging link between 3D genome misfolding due to repeat instability.  More than 30 inherited disorders are caused by unstable expansion of repetitive DNA sequences, including Huntington’s disease, amyotrophic lateral sclerosis, fragile x syndrome, and Friedreich’s ataxia.

Jennifer Phillips Cremins is an Assistant Professor in the Departments of Genetics and Bioengineering. Her lab focuses on understanding the epigenetic mechanisms that govern neural specification and synaptic plasticity in healthy neurons and how these epigenetic mechanisms go awry in neurodevelopmental and neurodegenerative diseases. You can read more here.