Mapping RNA splicing variations in clinically accessible and nonaccessible tissues to facilitate Mendelian disease diagnosis using RNA-seq. Joseph K. Aicher, Paul Jewell, Jorge Vaquero-Garcia, Yoseph Barash & Elizabeth J. Bhoj.

Joint profiling of chromatin accessibility and CAR-T integration site analysis at population and single-cell levels. Wenliang Wang, Maria Fasolino, Benjamin Cattau, Naomi Goldman, Weimin Kong, Megan A. Frederick, Sam J. McCright, Karun Kiani, Joseph A. Fraietta, and Golnaz Vahedi. 

Genetic Variation in Type 1 Diabetes Reconfigures the 3D Chromatin Organization of T Cells and Alters Gene Expression. Maria Fasolino, Naomi Goldman, Wenliang Wang, Benjamin Cattau, Yeqiao Zhou, Jelena Petrovic, Verena M. Link, Allison Cote,…

An Ancient Baboon Genome Demonstrates Long-Term Population Continuity in Southern Africa.  Iain Mathieson, Federico Abascal, Lasse Vinner, Pontus Skoglund, Cristina Pomilla, Peter Mitchell, Charles Arthur, Deepti Gurdasani, Eske Willerslev, Manj S Sandhu, Genevieve Dewar.

Integrative analysis reveals RNA G-quadruplexes in UTRs are selectively constrained and enriched for functional associations. David S. M. Lee, Louis R. Ghanem & Yoseph Barash

African-centric TP53 variant increases iron accumulation and bacterial pathogenesis but improves response to malaria toxin. Kumar Sachin Singh, Julia I-Ju Leu, Thibaut Barnoud, Prashanthi Vonteddu, Keerthana Gnanapradeepan, Cindy Lin, Qin Liu, James C. Barton, Andrew…

On the existence and functionality of topologically associating domains. Jonathan A. Beagan & Jennifer E. Phillips-Cremins.

Gcn5-Mediated Histone Acetylation Governs Nucleosome Dynamics in Spermiogenesis. Lacey J. Luense, Greg Donahue, Enrique Lin-Shiao, Richard Rangel, Angela H. Weller, Marisa S. Bartolomei, Shelley L. Berger.

miRNA142-3p targets Tet2 and impairs Treg differentiation and stability in models of type 1 diabetes. Martin G. Scherm, Isabelle Serr, Adam M. Zahm, Jonathan Schug, Saverio Bellusci, Rossella Manfredini, Victoria K. Salb, Katharina Gerlach, Benno Weigmann, Anette-Gabriele Ziegler, Klaus H. Kaestner & Carolin Daniel

Stress-Induced Neuron Remodeling Reveals Differential Interplay Between Neurexin and Environmental Factors in Caenorhabditis elegans. Michael P. Hart