Cohesin promotes stochastic domain intermingling to ensure proper regulation of boundary-proximal genes. Jennifer M. Luppino, Daniel S. Park, Son C. Nguyen, Yemin Lan, Zhuxuan Xu, Rebecca Yunker & Eric F. Joyce.

How Computational Experiments Can Improve Our Understanding of the Genetic Architecture of Common Human Diseases. Jason H. Moore, Randal S. Olson, Peter Schmitt, Yong Chen and Elisabetta Manduchi. 

Electronic health records and polygenic risk scores for predicting disease risk. Ruowang Li, Yong Chen, Marylyn D. Ritchie & Jason H. Moore.

Mapping RNA splicing variations in clinically accessible and nonaccessible tissues to facilitate Mendelian disease diagnosis using RNA-seq. Joseph K. Aicher, Paul Jewell, Jorge Vaquero-Garcia, Yoseph Barash & Elizabeth J. Bhoj.

Joint profiling of chromatin accessibility and CAR-T integration site analysis at population and single-cell levels. Wenliang Wang, Maria Fasolino, Benjamin Cattau, Naomi Goldman, Weimin Kong, Megan A. Frederick, Sam J. McCright, Karun Kiani, Joseph A. Fraietta, and Golnaz Vahedi. 

Genetic Variation in Type 1 Diabetes Reconfigures the 3D Chromatin Organization of T Cells and Alters Gene Expression. Maria Fasolino, Naomi Goldman, Wenliang Wang, Benjamin Cattau, Yeqiao Zhou, Jelena Petrovic, Verena M. Link, Allison Cote,…

An Ancient Baboon Genome Demonstrates Long-Term Population Continuity in Southern Africa.  Iain Mathieson, Federico Abascal, Lasse Vinner, Pontus Skoglund, Cristina Pomilla, Peter Mitchell, Charles Arthur, Deepti Gurdasani, Eske Willerslev, Manj S Sandhu, Genevieve Dewar.

Integrative analysis reveals RNA G-quadruplexes in UTRs are selectively constrained and enriched for functional associations. David S. M. Lee, Louis R. Ghanem & Yoseph Barash

African-centric TP53 variant increases iron accumulation and bacterial pathogenesis but improves response to malaria toxin. Kumar Sachin Singh, Julia I-Ju Leu, Thibaut Barnoud, Prashanthi Vonteddu, Keerthana Gnanapradeepan, Cindy Lin, Qin Liu, James C. Barton, Andrew…

On the existence and functionality of topologically associating domains. Jonathan A. Beagan & Jennifer E. Phillips-Cremins.