Julia I-Ju Leu, PhD

Research Associate Professor of Genetics

Department: Genetics

Selected Publications

• Shao, C., Indeglia, A., Foster, M., Casey, K., Leung, J., Modarai, S.R., Leu, J.I., Doung, B., Mes-Masson, A.M., Sims-Mourtada, J., Auslander, N., Drapkin, R., Bitler, B.G., Zhang, N., Murphy, M.E. : Mutant p53 binds and controls estrogen receptor activity to drive endocrine resistance in ovarian cancer Genes & Development. 40(3-4) : 199-214, 2026
• Stieg, D.C., Casey, K., Karisetty, B.C., Leu, J.I., Larkin, F., Vogel, P., Madzo, J., Murphy, M.E. : The Ashkenazi-centric G334R variant of TP53 is severely impaired for transactivation but retains tumor suppressor function in a mouse model Mol Cell Biol. 44(12) : 607-621, 2024
• IGVF Consortium : Deciphering the impact of genomic variation on function Nature 633(8028) : 47-57, 2024
• Indeglia, A., Leung, J.C., Miller, S.A., Leu, J.I., Dougherty, J.F., Clarke, N.L., Kirven, N.A., Shao, C., Ke, L., Lovell, S., Barnoud, T., Lu, D.Y., Lin, C., Kannan, T., Battaile, K.P., Yang, T.H.L., Batista Oliva, I., Claiborne, D.T., Vogel, P., Liu, L., Liu, Q., Nefedova, Y., Cassel, J., Auslander, N., Kossenkov, A.V., Karanicolas, J., Murphy, M.E. : An African-specific variant of TP53 reveals PADI4 as a regulator of p53-mediated tumor suppression Cancer Discovery 13(7) : 1696-1719, 2023
• Leung, J.C., Leu, J.I., Indeglia, A., Kannan, T., Clarke, N.L., Kirven, N.A., Dweep, H., Garlick, D., Barnoud, T., Kossenkov, A.V., George, D.L., Murphy, M.E. : Common activities and predictive gene signature identified for genetic hypomorphs of TP53. Proc. Natl. Acad. Sci. USA. 120(7) : e2212940120, 2023
• Leu, J.I., Murphy, M.E., George, D.L. : Targeting ErbB3 and cellular NADPH/NADP(+) abundance sensitizes cutaneous melanomas to ferroptosis inducers ACS Chemical Biology 17(5) : 1038-1044, 2022
• Leu, J.I., Murphy, M.E., George, D.L. : P53 regulates cellular redox state, ferroptosis and metabolism Molecular & Cellular Oncology 8(2) : 1877076, 2021
• Parris, J.L.D., Barnoud, T., Leu, J.I., Leung, J.C., Ma, W., Kirven, N.A., Poli, A.N.R., Kossenkov, A.V., Liu, Q., Salvino, J.M., George, D.L., Weeraratna, A.T., Chen, Q., Murphy, M.E. : HSP70 inhibition blocks adaptive resistance and synergizes with MEK inhibition for the treatment of NRAS-mutant melanoma Cancer Research Communications. 1(1) : 17-29, Oct 2021
• Singh, K.S., Leu*, J.I., Barnoud, T., Vonteddu, P., Gnanapradeepan, K., Lin, C., Liu, Q., Barton, J.C., Kossenkov, A.V., George, D.L., Murphy, M.E., Dotiwala, F. : African-centric TP53 variant increases iron accumulation and bacterial pathogenesis but improves response to malaria toxin Nature Communications 11(1) : 473, 2020. Notes: *Co-first author
• Leu, J.I., Murphy, M.E., George, D.L. : Functional interplay among thiol-based redox signaling, metabolism, and ferroptosis unveiled by a genetic variant of TP53 Proc. Natl. Acad. Sci. USA. 117(43) : 26804-26811, 2020
• Barnoud, T., Leung*, J.C., Leu*, J.I., Basu*, S., Poli*, A.N.R., Parris, J.L.D., Indeglia, A., Martynyuk, T., Good, M., Gnanapradeepan, K., Sanseviero, E., Moeller, R., Tang, H.Y., Cassel, J., Kossenkov, A.V., Liu, Q., Speicher, D.W., Gabrilovich, D.I., Salvino, J.M., George, D.L., Murphy, M.E. : A novel inhibitor of HSP70 induces mitochondrial toxicity and immune cell recruitment in tumors Cancer Research. 80(23) : 5270-5281, 2020. Notes: *Equal contribution
• Gnanapradeepan, K., Leu, J.I., Basu, S., Barnoud, T., Good, M., Lee, J.V., Quinn, W.J., Kung, C.P., Ahima, R., Baur, J.A., Wellen, K.E., Liu, Q., Schug, Z.T., George, D.L., Murphy, M.E. : Increased mTOR activity and metabolic efficiency in mouse and human cells containing the African-centric tumor-predisposing p53 variant Pro47Ser Elife 9 : e55994, 2020