Jonathan Schug, PhD

Adjunct Assistant Professor of Genetics

• Technical Director, Next-Generation Sequencing Core/Functional Genomics Core, University of Pennsylvania

Department: Genetics

Selected Publications

• Wang YJ, Traum D, Schug J, Gao L, Liu C; HPAP Consortium, Atkinson MA, Powers AC, Feldman MD, Naji A, Chang KM, Kaestner KH. : Multiplexed In Situ Imaging Mass Cytometry Analysis of the Human Endocrine Pancreas and Immune System in Type 1 Diabetes. Cell Metabolism 29 : 1-5, January 2019
• Condon, D. E., Tran, P. V., Lien, Y. C., Schug, J., Georgieff, M. K., Simmons, R. A., Won, K. J. : Defiant: (DMRs: easy, fast, identification and ANnoTation) identifies differentially Methylated regions from iron-deficient rat hippocampus BMC Bioinformatics 19(1) : 31, 2018
• Serr, I., Scherm, M. G., Zahm, A. M., Schug, J., Flynn, V. K., Hippich, M., Kalin, S., Becker, M., Achenbach, P., Nikolaev, A., Gerlach, K., Liebsch, N., Loretz, B., Lehr, C. M., Kirchner, B., Spornraft, M., Haase, B., Segars, J., Kuper, C., Palmisano, R., Waisman, A., Willis, R. A., Kim, W. U., Weigmann, B., Kaestner, K. H., Ziegler, A. G., Daniel, C. : A miRNA181a/NFAT5 axis links impaired T cell tolerance induction with autoimmune type 1 diabetes Sci Transl Med 10(422) 2018
• Nam, K. N., Wolfe, C. M., Fitz, N. F., Letronne, F., Castranio, E. L., Mounier, A., Schug, J., Lefterov, I., Koldamova, R. : Integrated approach reveals diet, APOE genotype and sex affect immune response in APP mice Biochim Biophys Acta 1864(1) : 152-161, 2018
• Gazala, S. A., Horwitz, E., Ben-Haroush Schyr, R., Bardugo, A., Israeli, H., Hija, A., Schug, J., Shin, S., Dor, Y., Kaestner, K. H., Ben-Zvi, D. : Sleeve Gastrectomy Improves Glycemia Independent of Weight Loss by Restoring Hepatic Insulin Sensitivity Diabetes 2018
• Castranio, E. L., Mounier, A., Wolfe, C. M., Nam, K. N., Fitz, N. F., Letronne, F., Schug, J., Koldamova, R., Lefterov, I. : Gene co-expression networks identify Trem2 and Tyrobp as major hubs in human APOE expressing mice following traumatic brain injury Neurobiol Dis 105 : 1-14, 2017
• Nam, K. N., Mounier, A., Wolfe, C. M., Fitz, N. F., Carter, A. Y., Castranio, E. L., Kamboh, H. I., Reeves, V. L., Wang, J., Han, X., Schug, J., Lefterov, I., Koldamova, R. : Effect of high fat diet on phenotype, brain transcriptome and lipidome in Alzheimer''s model mice Sci Rep 7(1) : 4307, 2017
• Li, C., Ackermann, A. M., Boodhansingh, K. E., Bhatti, T. R., Liu, C., Schug, J., Doliba, N., Han, B., Cosgrove, K. E., Banerjee, I., Matschinsky, F. M., Nissim, I., Kaestner, K. H., Naji, A., Adzick, N. S., Dunne, M. J., Stanley, C. A., De Leon, D. D. : Functional and Metabolomic Consequences of KATP Channel Inactivation in Human Islets Diabetes 66(7) : 1901-1913, 2017
• Lahens, N. F., Ricciotti, E., Smirnova, O., Toorens, E., Kim, E. J., Baruzzo, G., Hayer, K. E., Ganguly, T., Schug, J., Grant, G. R. : A comparison of Illumina and Ion Torrent sequencing platforms in the context of differential gene expression BMC Genomics 18(1) : 602, 2017
• Galivo, F., Benedetti, E., Wang, Y., Pelz, C., Schug, J., Kaestner, K. H., Grompe, M. : Reprogramming human gallbladder cells into insulin-producing beta-like cells PLoS One 12(8) : e0181812, 2017