Gerard D Schellenberg, PhD

Professor of Pathology and Laboratory Medicine

Department: Pathology and Laboratory Medicine

Graduate Group Affiliations

Contact Information

Department of Pathology and Laboratory Medicine
University of Pennsylvania Perelman School of Medicine
Room 605B, Stellar Chance Laboratories
422 Curie Blvd.
Philadelphia, PA 19104
Email: gerardsc@pennmedicine.upenn.edu

Education

  • B.S. (Biochemistry/Minor: Chemistry)
    University of California at Riverside, Riverside, CA, 1973
  • Ph.D. (Biochemistry/Minor: Cell Biology)
    University of California at Riverside, Riverside, CA, 1978

Post-Graduate Training

  • NIH Post Doctoral Fellowship
    National Institute of Health, 1980 - 1982
  • Senior Research Fellow
    Department of Genetics, School of Medicine, University of Washington, Seattle, WA, 1982 - 1983
  • Senior Research Fellow
    Division of Neurology, Department of Medicine, University of Washington, Seattle, WA, 1979 - 1982
  • Senior Research Fellow
    Department of Medical Genetics, School of Medicine, RG-20, University of Washington, Seattle, WA, 1978 - 1979
  • National Science Foundation Undergraduate
    Summer Research Program, Department of Biochemistry, University of California at Riverside, CA, 1972 - 1972
  • National Science Foundation Undergraduate Research Fellowship
    Summer Research Program, Department of Biochemistry, University of California at Riverside, California, 1972 - 1972

Selected Publications

  • Sonnen JA, Larson EB, Crane PK, Haneuse S, Li G, Schellenberg GD, Craft S, Leverenz JB, Montine TJ : Pathological correlates of dementia in a longitudinal, population-based sample of aging Ann Neurol 62(4) : 406-13, Oct 2007
  • Hopfner F, Tietz AK, Ruf VC, Ross OA, et al : Common variants near ZIC1 and ZIC4 in autopsy-confirmed multiple system atrophy Mov Disord 37(10) : 2110-2121, Oct 2022
  • Rademakers R, Baker M, Gass J, Adamson J, Huey ED, Momeni P, Spina S, Coppola G, Karydas AM, Stewart H, Johnson N, Hsiung G-Y, Kelley B, Kuntz K, Steinbart E, Wood EM, Yu C-E, Josephs K, Sorenson E, Womack KB, Weintraub S, Pickering-Brown SM, Schofield PR, Brooks WS, Van Deerlin VM, Snowden J, Clark CM, Kertesz A, Boylan K, Ghetti B, Neary D, Schellenberg GD, Beach TG, Mesulam M, Mann D, Grafman J, Mackenzie IR, Feldman H, Bird T, Petersen R, Knopman D, Boeve B, Geschwind DH, Miller B, Wszolek Z, Lippa C, Bigio EH, Dickson D, Graff-Radford N, Hutton M : Phenotypic variability associated with progranulin haploinsufficiency in patients with the common 1477C-->T (Arg493X) mutation: an international initiative Lancet Neurol 6(10) : 857-68, Oct 2007
  • Eissman JM, Dumitrescu L, Mahoney ER, et al : Sex differences in the genetic architecture of cognitive resilience to Alzheimer’s disease Brain 145(7) : 2541-2554, Jul 2022
  • Brickell KL, Leverenz JB, Steinbart EJ, Rumbaugh M, Schellenberg GD, Nochlin D, Lampe TH, Holm IE, Van Deerlin V, Yuan W, Bird TD : Clinicopathological concordance and discordance in three monozygotic twin pairs with familial Alzheimer's disease J Neurol Neurosurg Psychiatry 78(10) : 1050-5, Oct 2007
  • Rajabli, F., Beecham, G.W., Hendrie, H.C., Baiyewu, O., Ogunniyi, A., Gao, A., Kushch, N.A., Lipkin-Vasquez, M., Hamilton-Nelson, K.L., Young, Y.I., Dykxhoorn, D.M., Nuytemans, K., Kunkle, B.W., Wang, L, Jin, F., Liu, X., Feliciano-Astacio, B.E., Schellenberg, G.D., Dalgard, C.L., Griswold, A.J., Byrd, G.S., Reitz, C., Cuccaro, M.L., Haines, J.L., Pericak-Vance, M.A., : A locus at 19q13.31 significantly reduces the ApoE ε4 risk for Alzheimer’s Disease in African Ancestry PLoS Genet 18(7) : e1009977, Jul 2022
  • Kraemer BC, Schellenberg GD : SUT-1 enables tau-induced neurotoxicity in C. elegans Hum Mol Genet 16(16) : 1959-71, Aug 2007
  • Bellenguez C, Küçükali F, Jansen IE, et al : New insights on the genetic etiology of Alzheimer’s and related dementias Nat Genet 54(4) : 412-436, Apr 2022
  • Wassink TH, Hazlett HC, Epping EA, Arndt S, Dager SR, Schellenberg GD, Dawson G, Piven J : Cerebral cortical gray matter overgrowth in autism is associated with functional variation of the serotonin transporter gene Arch Gen Psychiatry 64(6) : 709-17, Jun 2007
  • Godrich G, Martin ER, Schellenberg GD, Pericak-Vance MA, Cuccaro M, Scott WK, Kukull W, Montine T, Beecham GW : Neuropathological lesions and their contribution to dementia and cognitive impairment in a heterogeneous clinical population Alzheimers Dement 18(12) : 2403-2412, Dec 2022
  • Yu C-E, Seltman H, Peskind ER, Galloway N, Zhou PX, Rosenthal E, Wijsman EM, Tsuang DW, Devlin B, Schellenberg GD : Comprehensive analysis of APOE and selected proximate markers for late-onset Alzheimer's disease: patterns of linkage disequilibrium and disease/marker association Genomics 89(6) : 655-65, Jun 2007
  • Vardarajan BN, Reyes-Dumeyer D, Piriz AL, Lantigua RA, Medrano M, Rivera D, Jiménez-Velázquez IZ, Martin E, Pericak-Vance MA, Bush W, Farrer L, Haines JL, Wang LS, Leung YY, Schellenberg G, Kukull W, De Jager P, Bennett DA, Schneider JA; Alzheimer's Disease Sequencing Project, Mayeux R : Progranulin mutations in clinical and neuropathological Alzheimer's disease Alzheimers Dement 18(12) : 2458-2467, Dec 2022
  • Galasko D, Salmon D, Gamst A, Olichney J, Thal LJ, Silbert L, Kaye J, Brooks P, Adonay R, Craig U-K, Schellenberg G, Borenstein AR : Prevalence of dementia in Chamorros on Guam: relationship to age, gender, education, and APOE Neurology 68(21) : 1772-81, May 2007
  • Kuksa PP, Liu C-L, Fu W, Qu L, Zhao Y, Katanic Z, Kuzma AB, Ho P-C, Tzeng K-T, Valladares O, Chou S-Y, Naj AC, Schellenberg GD, Wang L-S, Leung YY : Alzheimer's Disease variant portal: a catalog of genetic findings for Alzheimer's Disease J Alzheimers Dis 86(1) : 461-477, 2022
  • Leverenz JB, Yu CE, Montine TJ, Steinbart E, Bekris LM, Zabetian C, Kwong LK, Lee VM-Y, Schellenberg GD, Bird TD : A novel progranulin mutation associated with variable clinical presentation and tau, TDP43 and alpha-synuclein pathology Brain 130(Pt 5) : 1360-74, May 2007
  • Holstege H, Hulsman M, Charbonnier C, et al : Exome sequencing identifies rare damaging variants in ATP8B4 and ABCA1 as novel risk factors for Alzheimer’s Disease Nat Genet 54(12) : 1786-1794, Dec 2022
  • Borenstein AR, Mortimer JA, Schofield E, Wu Y, Salmon DP, Gamst A, Olichney J, Thal LJ, Silbert L, Kaye J, Craig UL, Schellenberg GD, Galasko DR : Cycad exposure and risk of dementia, MCI, and PDC in the Chamorro population of Guam Neurology 68(21) : 1764-71, May 2007
  • Gao Y, Felsky D, Reyes-Dumeyer D, Sanjeev S, Rentería MA, Ma Y, Klein H, Cosentino S, De Jager P, Bennett DA, Brickman AM, Schellenberg GD, Mayeux R, Barral S : Integration of GWAS and brain transcriptomic analyses in a multi-ethnic sample of 35,245 older adults identifies DCDC2 gene as predictor of episodic memory maintenance Alzheimers Dement 18(10) : 1797-1811, Oct 2022