Richard Edmund Phillips, MD/PhD

Voorhees Presidential Professor

• Chief, Division of Neuro-Oncology, Department of Neurology, Perelman School of Medicine, University of Pennsylvania
• Neuro-Oncology Fellowship Director, Department of Neurology, Perelman School of Medicine, University of Pennsylvania

Department: Neurology

Selected Publications

• Lagan E, Gannon D, Silva AJ, Bibawi P, Doherty AM, Nimmo D, McCole R, Monger C, Genesi GL, Vanderlinden A, Innes JA, Jones CLE, Yang L, Chen B, van Mierlo G, Jansen PWTC, Pednekar C, Von Kriegsheim A, Wynne K, Sánchez-Rivera FJ, Soto-Feliciano YM, Carcaboso AM, Vermeulen M, Oliviero G, Chen CW, Phillips RE, Bracken AP, Brien GL : A specific form of cPRC1 containing CBX4 is co-opted to mediate oncogenic gene repression in diffuse midline glioma Molecular Cell 85(11) : 2110-2127, Jun 2025
• Till JE, Seewald NJ, Yazdani Z, Wang Z, Ballinger D, Samberg H, Dandu S, Macia C, Yin M, Abdalla A, Prior T, Shah SS, Patel T, McCoy E, Mansour M, Wills CA, Bochenek V, Serrano J, Snuderl M, Phillips RE, O'Rourke DM, Amankulor NM, Nabavizadeh A, Desai AS, Gollomp K, Binder ZA, Zhou W, Bagley SJ, Carpenter EL. : Corticosteroid-Dependent Association between Prognostic Peripheral Blood Cell-Free DNA Levels and Neutrophil-Mediated NETosis in Patients with Glioblastoma Clin Cancer Res 31 : 1292-1304, Apr 2025
• Dáire Gannon, Eimear Lagan, Ademar Jesus Silva, Peter Bibawi, Anthony M. Doherty, Darragh Nimmo, Rachel McCole, Craig Monger, Giovani Genesi, Aurelie Vanderlinden Dibekeme, James A. Innes, Lu Yang, Bryan Chen, Guido van Mierlo, Pascal W.T.C Jansen, Keiran Wynne, Fran-cisco J. Sánchez-Rivera, Yadira M. Soto-Feliciano, Michiel Vermeulen, Giorgio Oliverio, Chun-Wei Chen, Richard E. Phillips, Adrian P. Bracken, Gerard L. Brien : Specific cPRC1 complexes are co-opted to mediate oncogenic gene repression in diffuse midline glioma Biorxiv December 2023
• Liang R., Tomita D. Sasaki Y., Ginn J,, Michino M., Huggins D., Baxt L., Kargman S., Shahid M., Kazuyoshi A., Duggan M., Stamford A., DeStanchina E., Liverton N., Meinke P., Foley M., Phillips R.E. : A chemical strategy toward brain penetrant EZH2 inhibitors ACS Medicinal Chemistry Letters 13(3) : 377–387, Feb 2022
• Phillips RE, Soshnev AA, Allis CD. : Epigenomic Reprogramming as a Driver of Malignant Glioma. Cancer Cell 38(5) : 647-660, Nov 2020
• Phillips RE, Soshnev AA, Allis CD. : Epigenomic Reprogramming as a Driver of Malignant Glioma Cancer Cell 38 : 647-660, Nov 2020
• Phillips, R. E., Yang, Y., Smith, R. C., Thompson, B. M., Yamasaki, T., SotoFeliciano, Y. M., Funato, K., Liang, Y., Garcia-Bermudez, J., Wang, X., Garcia, B. A., Yamasaki, K., McDonald, J. G., Birsoy, K., Tabar, V., & Allis, C. D. : Target identification reveals lanosterol synthase as a vulnerability in glioma Proceedings of the National Academy of Sciences of the United States of America 116(16) : 7957–7962, Apr 2019
• Phillips, R. E., Curran, K. J., & Khakoo, Y : Management of late extraneural recurrence of medulloblastoma without high-dose chemotherapy. Journal of Neuro-Oncology 124(3) : 523–524, Sep 2015
• Awosika, O. O., Lyons, J. L., Ciarlini, P., Phillips, R. E., Alfson, E. D., Johnson, E. L., Koo, S., Marty, F., Drew, C., Zaki, S., Folkerth, R. D., & Klein, J. P. : Fatal adenovirus encephalomyeloradiculitis in an umbilical cord stem cell transplant recipient. Neurology 80(18) : 1715–1717, Apr 2013
• Bartel, G., Brown, K., Phillips, R., Peng, Q., Zhou, W., Sacks, S. H., & Wong, W. : Donor specific transplant tolerance is dependent on complement receptors Transplant International 26(1) : 99-108, Jan 2013