About the Facility

Located within the Perelman School of Medicine at the University of Pennsylvania, the Genetically Engineered Mouse Core (GEMC) is a state-of-the-art facility specializing in advanced mouse genome editing services. Utilizing the latest CRISPR-Cas9 technologies, we offer high-precision genome editing solutions to support a broad range of biomedical research.

In collaboration with the CRISPR/Cas9 Mouse Targeting Core we employ cutting-edge techniques to efficiently and cost-effectively generate custom genetically modified mouse models. Focused on innovation, efficiency, and quality, we help researchers accelerate discoveries through reliable and precise genetic modifications.

As a key component of Penn’s translational research ecosystem, the GEMC serves both internal investigators and external collaborators. We provide tailored project design, expert consultation, and technical support. Whether you need conditional knockouts, point mutations, reporter lines, or complex multi-gene modifications, our facility is equipped to deliver results with scientific rigor and excellence. GEMC also produces transgenic mice by DNA pronuclear injection and chimeric mice by embryonic stem cell incorporation into blastocysts.

Additionally, the GEMC offers sperm and embryo cryopreservation, in vitro fertilization, and the re-derivation of both live and cryopreserved lines. Our cryopreservation facility ensures the long-term storage of mouse sperm and embryo samples, safeguarding valuable genetic resources for future research.

Location:

The GEMC is located on the basement level of the Clinical Research Building. To maintain the highest standards of quality and infection control, the facility operates behind a strict microbiological barrier with controlled access. Mice are housed in sterile conditions using autoclaved cages, bedding, and microisolator units to prevent contamination.

38-40 Clinical Research Building

Mailing Address:

500 Clinical Research Building
415 Curie Boulevard
Philadelphia, PA 19104-6145
Telephone: 215-573-3023
Fax: 215-573-5892